Habitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM.

We have developed novel caffeine derivatives that markedly reduce PCSK9 expression/secretion.

In hepatocytes, caffeine is known to suppress SREBF2 activity, which reduces PCSK9 expression, and thus increases LDLR expression

This ground-breaking research suggested that PCSK9 could degrade CD36

coffee components can influence lipid and cancer metabolism by regulating adipogenesis and carcinogenesis

caffeine has been demonstrated to enhance hepatic ER-linked Ca2+ levels and inhibit the transcriptional activation of SREBP2

Caffeine inhibits the expression of SREBP2 at the transcriptional level by increasing the Ca2+ concentration in the hepatic ER

To reduce ER stress, Lebeau et al. screened for compounds that enhance ER-entry of Ca2+